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Albert Hofmann In 1943 the results of the first period of my research in the ergot field were published in a professional journal, Helvetica Chimica Acta. As a result of my first eight years of ergot research, I synthesized a large number of ergot derivatives: amides of lysergic acid, lysergic acid being the characteristic nucleus of natural ergot alkaloids. Among these amides of lysergic acid there was also the diethylamide of lysergic acid. I would say that LSD was the outcome of a complex process.