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Horatio Caine Horatio Caine, portrayed by David Caruso, is the head of the crime lab in Miami. He's a tough guy with a heart of gold, and he's always there to solve the case. Horatio Caine Horatio Caine, portrayed by David Caruso, is the head of the crime lab in Miami. He's a tough guy with a heart of gold, and he's always there to solve the case. Horatio Caine Horatio Caine, portrayed by David Caruso, is the head of the crime lab in Miami. He's a tough guy with a heart of gold, and he's always there to solve the case.